Extreme and life-threatening thrombocytopenia has been reported throughout therapy with GAZYVA together with chemotherapy. Monitor all patients often for thrombocytopenia and hemorrhagic occasions, particularly throughout the primary cycle and if clinically indicated, consider laboratory coagulation parameters. In patients with Grade three or four thrombocytopenia, monitor platelet counts extra often till decision and consider dose delays of GAZYVA and chemotherapy or dose reductions of chemotherapy. Transfusion of blood merchandise (i.e., platelet transfusion) could also be obligatory. Fatal and extreme DIC has been reported in patients receiving GAZYVA for therapy of follicular lymphoma and chronic lymphocytic leukemia. The vast majority of DIC instances have concerned adjustments in platelets and laboratory coagulation parameters following the primary infusion, with spontaneous decision often occurring by Day 8. In some circumstances, DIC was related to IRRs, TLS, or each. In patients with suspected DIC, consider potential causes, and monitor coagulation parameters, platelet counts, and for indicators and signs of bleeding or thrombosis. Handle in accordance to plain tips for DIC.

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